CUTTING EDGE APPROACHES
to DRUG DESIGN

 


Programme

  9.15 Registration and Coffee

10.00

Welcome and Introduction

10.10

PLENARY LECTURE

The future of bioinformatics and its impact on drug discovery

Professor Janet Thornton (University College London)

11.00

Sense and sensitivity in sequence analysis: Bioinformatics after target discovery

Dr David Parry-Smith (BioFocus)

11.40

COFFEE

12.00

Making lead discovery less complex

Dr Mike Hann (GlaxoSmithKline)

view powerpoint presentation

12.40

Recent advances in virtual screening: Scoring of protein-ligand interactions

Dr Alexander Alex (Pfizer)

1.10

LUNCH

2.00

In silico predictions of ADME properties: Today’s approaches and future directions

Dr Han van de Waterbeemd (Pfizer)

2.40

Hit to lead case studies

Dr Andrew Baxter (AstraZeneca) 

3.10

TEA

3.40

From de novo structure-based design to pharmacophore fingerprinting and combinatorial library design: Experiences with factor Xa inhibitors

Dr Jonathan Mason (Pfizer)

4.20

Lead hopping and focused library design applied to the synthesis of activators of the nitric oxide
sensor- soluble guanylate cyclase

Dr David Sellwood (The Wolfson Institute for Biomedical Research)

view powerpoint presentation

5.00

CLOSE